The KCNQ2 antibody - middle region (ARP35459_T100) from Aviva Systems Biology is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The KCNQ2 antibody - middle region (ARP35459_T100) has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1)